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Record identifier : 566282
Personal Name - Primary Intelectual Responsibility : Webster, Linda Jean
Title and statement of responsibility : Treatment of erectile dysfunction in males with moderate heart failure: Impact on depressive symptoms [Thesis]
Publication, Distribution,Etc. : University of Alberta (Canada, 2002
Language of the Item : eng
Dissertation of thesis details and type of degree : M.N
Body granting the degree : , University of Alberta (Canada
Summary or Abstract : Although sildenafil is efficacious in treating ED, use in CHF is relatively contraindicated due to hypotensive concerns. It is proposed that ED, depression and CHF form a reinforcing triad. The purposes were to determine whether treatment of ED with sildenafil in males with moderate CHF would improve depressive symptoms, as well as validation of two depression indices. Thirty-five men were randomized into a 12-week, cross-over trial, comparing sildenafil to placebo. The International Index of Erectile Function (IIEF), Beck Depression Index (BDI), and Center of Epidemiologic Studies-Depression (CES-D) scales were completed at baseline, and after 4 weeks of sildenafil/placebo. ANOVA and Fisher's PSLD were used. Sildenafil was effective in improving the IIEF score (p < 0.0001). This was associated with decrease in BDI (p < 0.005) and CES-D (p < 0.003) scores, which showed 83 concordance. Effective treatment of ED is associated with improvement of depression in patients with moderate CHF. The BDI and CES-D indicated concordance.
Topical Name Used as Subject : Nursing, Physiological psychology, Pharmaceuticals, Medical disorders, Heart failure, Mental depression, Men
Information of biblio record : TL
 
 
 
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