خط مشی دسترسی
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Singh, Amber L.
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A behavior genetic study of associations between negative emotionality and childhood psychiatric disorders [Thesis]
Emory University, 2007
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Summary or Abstract
Current models of the development of psychopathology assert that temperament characteristics play an important etiological role in the development of both internalizing and externalizing psychopathology. The goal of these two studies was to investigate the etiology of the covariation of negative emotionality (NE) and (1) major depressive disorder (MDD), generalized anxiety disorder (GAD), and separation anxiety disorder (SAD) symptom dimensions and (2) Oppositional Defiant Disorder (ODD), Conduct Disorder (CD), Inattention, and Hyperactivity using multivariate behavior genetic model-fitting methods in two independent, community-based twin samples. Results univariate biometric model fitting analyses as well as phenotypic correlations are consistent with the extant literature suggesting moderate correlations between NE and each of the symptom dimensions, as well as genetic and nonshared environmental influences underlying NE and each symptom dimension, with evidence from one sample suggesting additional shared environmental influences on internalizing disorders. Analyses investigating the etiology of the phenotypic associations, MDD and GAD showed common genetic influences with NE with evidence for additional disorder-specific genetic influences. In contrast, the shared environmental influences underlying all internalizing symptom dimensions were shared entirely with those that underlie NE. Associations between NE and ODD and CD were due in part to genetic influences shared in common with NE with additional evidence for disorder-specific genetic influences. The two samples yielded discrepant results with respect to Inattention and Hyperactivity, thus further research is necessary to clarify the role of NE in the etiology of ADHD. Limitations, implications, and future directions of each study are discussed..
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